Every one of the 3 main ingredients in clear & confident has been documented in medical journals throughout the world.
E Zander and S Weisman, 1992 reviewed several studies and concluded that salicylic acid reduced the number of primary lesions and therefore the number and severity of all lesions associated with pimples.
In 1981 A R Shalita, a professor of dermatology at the State university of New York, published the results of a study of patients with mild to moderate acne. He concluded that the patients had a significant reduction in inflammatory lesions and open comedones as a result of using salicylic acid.
Source: A. R. Shalita, “Treatment of Mild and Moderate Acne Vulgaris with Salicylic Acid,” Cutis, vol28, no.5 , November 1981, 556-558.
Dr Kligman wrote “ No prescription antibiotic can begin to match the antibacterial efficacy of benzoyl peroxide”
Source: A.M. Kligman, “Acne Vulgaris: Tricks and Treatments. Part II: The Benzoyl Peroxide Saga,” Cutis, vol.56, no.2, November 1995, 260.).
Dr V B Patel 2001 found in a study that BP was as effective as topical tretinoin in the percentage reduction in the total number of skin lesions.
V. B. Patel et al., “Preparation and Comparative Clinical Evaluation of Liposomal Gel of Benzoyl Peroxide for Acne”, Drug Development Ind Pharm, vol 27, no.8, September 2001, 863-869.
Dr Leydon 2001 conducted a ten week double blind study of 492 patients in which he and his colleagues compared BP alone with BP combined with erythromycin. The results were impressive, in both versions patients showed significant improvement in their inflammatory lesions.
J. Leyden et al., “Comparison of the Efficacy and Safety of a Combination of Topical Gel Formulation of Benzoyl Peroxide and Clindamycin with Benzoyl Peroxide, Clindamycin and Vehicle Gel in the Treatments of Acne Vulgaris,” American Journal of Clinical Dermatology, vol.2, no.1, 2001, 33-39).
In 2000, a study in Turkey on 58 women it was concluded that glycolic acid helped repair pimples and long term use of a low strength may have some useful effects on scars. They also concluded that glycolic acid has considerable therapeutic value for acne but with minimal side effects in Asian skin.
Z. Erbagci And C. Akcali, “ Biweekly Serial Glycolic Acid Peels vs. Long Term Daily use of Topical Low Strength Glycolic Acid in the Treatment of Atrophic Acne Scars”, International Journal of Dermatology, vol39, no.10, October 2000, 789-94
In 1998 research in Australia concluded that when 5% glycolic cream was compared with a placebo cream (double blind study), after 3 month of daily use, the patients who had used the glycolic showed a statistically significant improvement in general skin texture and discoloration.
P. K. Thibault et al., “ A Double Blind Randomised Clinical Trial on the Effectiveness of a Daily Glycolic Acid 5% Formulation in the Treatment of Photoaging”. Dermatologic Surgery, vol 24, no.5 , May 1998, 573-78